These experiments, in part, confirmed the effects from our metabolic analyses; for example, the reduced expression of glucose metabolism genes and highly significant upregulation of fatty acid metabolism genes in KO mice upon HFD.
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C1q and Tumor Necrosis Factor Related Protein 9 Protects from Diabetic Cardiomyopathy by Alleviating Cardiac Insulin Resistance and Inflammation.
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To investigate the impact of CTRP9 overexpression on cardiac glucose uptake, we conducted dynamic FDG PET scans, which showed a trend towards increased FDG uptake in the heart of AAV-CTRP9 compared to AAV control during HFD ( Figure 6 A,B).