Enhanced Antitumor Efficacy of Radium-223 and Enzalutamide in the Intratibial LNCaP Prostate Cancer Model.

Int J Mol Sci · 2023 · PMC9916479 · PMID 36768509

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a decreasing trendno p-value reported

A decreasing trend in the total area of tumor-induced abnormal bone was associated with the combination treatment.

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did not reach statistical significanceno p-value reported

The relative number of osteoblasts in the tumor-bearing tibiae was reduced by radium-223 monotherapy ( p < 0.001) and the combination treatment ( p = 0.04) compared with vehicle ( Figure 5 A,B), while the reduction upon combination treatment did not reach statistical significance in the non-tumor-bearing bone ( Figure 5 C).

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