Dietary Walnuts Preserve Aspects of Health Span and Alter the Hippocampal Lipidome in Aged High-Fat Diet-Fed Mice.

Finally, when comparing HFD to LFD, ENSMUSG00000019710 ( MRPl24 ) and ENSMUSG00000019987 ( ARG1 ) were most closely approaching significance.

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However, these effects appear to be somewhat complex and were largely driven by reductions in several saturated or monounsaturated containing PC species, as well as LPE (22:5) and FFA (22:5), and overall PC content, with a notable trend in reduced CER levels.

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In spite of some favorable signals related to metabolic health, including a reduction in presumed hepatic fat accumulation, as has been observed [ 47 ], as well as improved cognition with walnut intake in this study, the effect on overall survival with walnuts, though suggestive, failed to reach significance.

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