Mechanisms of Prostate Cancer Cells Survival and Their Therapeutic Targeting.

Although the primary analysis did not reach statistical significance, the update analysis showed an OS benefit of apalutamide (median OS not reached v 52.2 mos; HR 0.65; 95% CI 0.53–0.79; p < 0.0001) despite crossover that was allowed in the study [ 209 ].

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