Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy.

Although it did not reach statistical significance, this result corroborates the transcriptomic data that associate increased POSTN levels with reduced survival in CMS4 patients (Supplementary Fig. 7d,e ).

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Yet, their expression consistently followed a decreasing trend over time paralleling the one observed for oxaliplatin uptake, thus suggesting a potential association between platinum intracellular concentration and TGF-beta activity.

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