Does the likelihood of malignancy in thyroid nodules with RAS mutations increase in direct proportion with the allele frequency percentage?

J Otolaryngol Head Neck Surg · 2023 · PMC9921308 · PMID 36774522

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0500

boldest claim

The sentences

did not achieve significancep > 0.05actually significant

81%), this did not achieve significance in Chi-squared analysis ( p > 0.05).

also in 1,397 other papers

did not reach statistical significanceno p-value reported

Multivariate analysis found a trend between RAS , a second genetic alteration and malignancy, but it did not reach statistical significance.

also in 111,027 other papers

a positive trendno p-value reported

On multivariate analysis, there was a positive trend between second genetic alteration and malignancy ( r = 1.97), but no statistically significant relationship was found between allele frequency, other genetic alterations, and cancer risk (all p > 0.05).

also in 11,005 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.