Transcriptome-wide association study of circulating IgE levels identifies novel targets for asthma and allergic diseases.

Front Immunol · 2023 · PMC9922991 · PMID 36793728

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nominally significantno p-value reported

Bi-directional MR analysis revealed four genes ( CLC , CCDC21 , S100A13 , and GCNT1 ) as nominally significant ( P mRNA→IgE < 0.05) causal regulators of IgE concentration without reverse causal effect ( P IgE->mRNA > 0.05), suggesting that individual gene transcripts that are associated with IgE concentration likely contribute causally to IgE regulation.

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