Expression of Gα o consistently resulted in a noticeable decrease in the pull down of Gα q -QP and Gα q -RC with Gβγ, but this did not reach statistical significance due to the already low level of Gα q -QP and Gα q -RC association with Gβγ in the absence of Gα o expression.
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Disruption of the interaction between mutationally activated Gα<sub>q</sub> and Gβγ attenuates aberrant signaling.
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