The major role of <i>sarA</i> in limiting <i>Staphylococcus aureus</i> extracellular protease production <i>in vitro</i> is correlated with decreased virulence in diverse clinical isolates in osteomyelitis.

Mutation of sarA, mgrA or rot did result in a statistically significant reduction in new bone formation ( Figure 3(c) ), and mutation of mgrA or rot resulted in significantly decreased bacterial burdens while mutation of sarA resulted in a downwards trend that did not reach statistical significance (p-value 0.0526) ( Figure 3(d) ).

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