Estimating the impact of stimulant use on initiation of buprenorphine and extended-release naltrexone in two clinical trials and real-world populations.

Although many of our generalized results failed to reach statistical significance, previous research has generally shown a negative association between stimulant use, especially MA, and MOUD initiation, with effect sizes similar to those observed in our study [ 11 – 13 , 46 , 47 ].

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