Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots.

Reassuringly, the association with a clinical diagnosis of “vitamin D deficiency” (ICD-10 E55; N cases = 3150, N noncases = 344,619) was negative and nominally significant (i.e., higher DBP associated with a reduced risk of a clinical diagnosis of vitamin D deficiency; beta = −0.07, standard error = 0.02, P value < 1.9 × 10 −4 ).

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Of the 143 genome-wide significant COJO SNPs in the UKB 25OHD GWAS, only the most highly significant one was replicated in our 25OHD sample.

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