The role of thymus- and extrathymus-derived regulatory T cells in maternal-fetal tolerance.

Compared with DT-treated Foxp3 DTR mice, adoptive transfer of thymus and spleen Treg cells or in vitro generated iTreg cells significantly decreased the percentages of decidua IFN-γ + cells ( p < 0.01, respectively), which did not differ from those of vehicle-treated control mice ( Figure 7C ).Compared with DT-treated Foxp3 DTR mice, adoptive transfer of thymus and spleen Treg cells or in vitro generated iTreg cells decreased the percentages of peripheral blood and decidua IL-17 + cells, but the differences did not reach statistical significance ( Figures 7B, D ).

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