Large-scale organoid study suggests effects of trisomy 21 on early fetal neurodevelopment are more subtle than variability between isogenic lines and experiments.

Tests of differences in estimated cell-type composition between trisomic and disomic organoids indicated nominally significant differences ( p < 0.05 by Welch’s t -test before multiple hypotheses correction) for three cell-types—glial progenitor cells, cortical neurons, and interneuron—but after Bonferroni-correction these were no longer statistically significant, with p ≥ 0.23 for all cell-types (see Supplementary Table 1 ).

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