<i>In-vivo</i> time course of organ uptake and blood-brain-barrier permeation of poly(L-lactide) and poly(perfluorodecyl acrylate) nanoparticles with different surface properties in unharmed and brain-traumatized rats.

Front Neurol · 2023 · PMC9939480 · PMID 36814997

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a clear trendno p-value reported

A clear trend for higher NP uptake in the perilesional area compared to the hippocampus was observed for all NP-types at 4 and 24 h.

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an overall trendno p-value reported

An overall trend of reduction in NP accumulation was evidenced after 24 h in all organs, except for PFDL-SDS accumulation in the spleen and the kidney, for which a trend to higher accumulation was observed after 24 h ( Figure 5 ).

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highly significantno p-value reported

In addition, a highly significant difference in NP accumulation between the BBB-injured and BBB-intact areas in CCI subjects was observed.

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