The T RM -promoting factors Prdm1 and Hic1 30 , 38 , 39 were downregulated, while the T CM -promoting factors Eomes and Klf2 40 , 41 showed a trend of increase with no difference in Runx3 , Zfp683 (Hobbit), and Tbx21 (T-bet) ( Figure 2D ).
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The aryl hydrocarbon receptor cell intrinsically promotes resident memory CD8<sup>+</sup> T cell differentiation and function.
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