Subgingival microbiome at different levels of cognition.

In multivariate linear models, alpha diversity did not associate with MMSE categories, but gender, number of teeth, caries and PPD were significantly associated in either of the cohorts ( Table 2 ). In univariate analysis, differences were observed in the beta-diversity between the MMSE categories, but they did not reach statistical significance (MINOPAR, p = 0.163; FINORAL, p = 0.077).

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In the present study, the relative abundance of only a few genera correlated significantly with the MMSE categories: Streptococcus and Actinomyces displayed a decreasing trend, while Tannerella , Treponema , Corynebacterium , and Saccharibacteria [G-5] presented an increasing trend with declining cognition.

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