Reduced insulin signaling in neurons induces sex-specific health benefits.

Furthermore, male lKO and fKO mice were not long-lived but showed a trend toward increased glucose tolerance.

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However, there was a notable trend in nighttime male Irs1KO activity (fig.

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In contrast, we only detected a small trend for increased EIF2A phosphorylation, suggesting that EIF2A phosphorylation might not be the main driver for IRS1-dependent ISR.

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