Discussion The results of the CHEOPS study did not reach statistical significance, but showed a modest potential benefit of combining hormone therapy and metronomic chemotherapy in metastatic breast cancer HR + /HER2− pre-treated with endocrine therapy (HR 0.73, 95% CI 0.50–1.06, log-rank P value = 0.0929).
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CHEOPS trial: a GINECO group randomized phase II assessing addition of a non-steroidal aromatase inhibitor to oral vinorelbine in pre-treated metastatic breast cancer patients.
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