THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass.

Though fed insulin only showed a trend towards increase (Fig. 7d ), Thada -KO mice displayed significantly improved glucose tolerance compared to their WT littermates after HFHS feeding for 12 weeks (Fig. 7 e, f), without change in insulin sensitivity (Fig. 7 g, h).

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