Signature of miRNAs derived from the circulating exosomes of patients with amyotrophic lateral sclerosis.

Moreover, we found the expression of hsa-miR-30b-5p, and the disease progression in patients with ALS showed a potentially positive correlation ( r = 0.2499, p = 0.0521, simple linear regression: Y = 0.5408*X + 0.9906) and a potentially negative correlation between the expression of hsa-miR-30b-5p and ALSFRS scores ( r = −0.2169,95% CI: −0.4524 to 0.04684, p = 0.096), although they did not reach statistical significance ( Supplementary Figure 4B ).

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