FK506-Binding Protein like (FKBPL) Has an Important Role in Heart Failure with Preserved Ejection Fraction Pathogenesis with Potential Diagnostic Utility.

Following 48 h exposure of H9C2 cells to Ang-II, AD-01 or Ang-II + AD-01, the only statistically significant change was observed in FKBPL mRNA expression after AD-01 treatment ( p < 0.05), and although BNP and ANP mRNA expression showed a trend towards an increase, this was not statistically significant at 48 h ( Figure 2 D–F).

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In further evaluating the biomarker potential of FKBPL in HFpEF, FKBPL plasma concentrations were found to be significantly increased when comparing the control group to acute HFpEF and only showed an increasing trend in HCM—suggesting a mechanistic role for FKBPL in the pathophysiology and progression of HFpEF.

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