Amyloid-PET and White Matter Hyperintensities Have Independent Effects on Baseline Cognitive Function and Synergistic Effects on Longitudinal Executive Function.

Testing the Interaction Term and the Main Effect of Global and Regional Aβ Burden and WMHs with Cognition The moderation regression analysis detected a marginally statistically significant interaction effect between Aβ burden and WMHs in relation to baseline EF ( p -value = 0.061), and a significant interaction term between the biomarkers in relation to longitudinal executive functions with p -value = 0.036.

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Results demonstrated that neither global Aβ SUVr (see Figure 2 C,D) nor regional Aβ SUVr mediates these associations as the CI for the indirect effect was crossing the zero and did not reach statistical significance.

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The regional models examining the interaction between Aβ burden in discrete cortical regions and WMH volumes detected marginally significant interaction between frontal, parietal and cingulate Aβ burden and WMHs in relation to baseline EF performance with p -value 0.061, 0.059 and 0.071, respectively.

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