Integrin αvβ3 Is a Master Regulator of Resistance to TKI-Induced Ferroptosis in HER2-Positive Breast Cancer.

Importantly, a comparison of 38 cancer cell lines found a highly significant correlation between high integrin β3 gene copy number and neratinib (Pearson correlation coefficients: 0.614, p -value = 4.12 × 10 −5 ) or lapatinib (Pearson correlation coefficients: 0.436, p -value = 1.13 × 10 −2 ) resistance ( Figure 2 E).

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These trends were also maintained when only HER2-positive cell lines were selected but did not reach statistical significance due to the limited number of data points.

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