Targeting Ubiquitin-like Protein, ISG15, as a Novel Tumor Associated Antigen in Colorectal Cancer.

Further, regulatory T cells (Tregs, CD4 + FoxP3 + ) tended to be lower in the Lm-LLO-ISG15-treated tumors, although the difference did not reach statistical significance ( Figure 3 G).

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We observed an increasing trend in the number of functional CD4 + T cells from the mice treated with Lm-LLO-ISG15 compared to CD4 + T cells from PBS, although statistical significance was not met ( Figure 3 I,J and Figure S3A–C ).

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