Effects of helminths and anthelmintic treatment on cardiometabolic diseases and risk factors: A systematic review.

In clusters that received community-wide intensive anthelminthic treatment with quarterly single-dose praziquantel and triple-dose albendazole, the mean LDL increased after 4 years of follow-up, as compared to the mean LDL in communities that received single-dose anthelmintic treatment, which was a significant trend (2.86 vs 2.60 mmol/L; adjusted mean difference, 0.26 [95% CI, −0.03 to 0.56]; P = .08).

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In contrast, the single study with positive associations reported elevated systolic, diastolic, and mean arterial blood pressures in pregnant women with hookworm infection, and a 6-fold increased odds of elevated mean arterial pressure in those with Trichuris , of borderline significance [ 92 ].

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