Characterization of De Novo Promoter Variants in Autism Spectrum Disorder with Massively Parallel Reporter Assays.

We did observe a nominally significant ( p = 0.016 Wilcoxon rank sum test) greater functional impact for HcDNV inhibitors in ASD cases than controls ( Figure 2 D–F), though this did not survive correction for the four equivalent conditions, so does not constitute evidence of a functional effect based on ASD diagnostic status ( Supplementary Note S1 and Figure S5 ).

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