Bodyweight A three-way ANOVA evaluating change in bodyweight from 4 months (time of irradiation) to 11 months (beginning of behavior tests) of age revealed an unexpected highly significant main effect of radiation exposure ( p = 0.01) and an expected significant effect of sex ( p = 0.04) ( Figure 1 C).
For IL-10, we observed no pairwise differences between groups but noted an overall trend towards significance of an interaction effect between dose and genotype, as the 0.5 Gy irradiated group is slightly lower compared to sham and 2 Gy groups in male and female Tg mice but slightly higher in male and female WT mice ( Figure 7 G).
For the CA3 region, the ANOVA revealed a trend for a main effect of sex, and multiple comparisons showed a trend for more SYP in 0.5 Gy but not 2 Gy irradiated F WT mice compared to their sham irradiated counterparts ( Figure 6 ). 2.8.
This group also displayed a statistical trend for an increased percentage of entries into the open arms relative to closed arms of the elevated plus maze, which could be an indication of reduced anxiety ( Figure 2 F).
We observed a trend towards significance for a reduction in R1282 staining in male 2 Gy mice relative to both male 0.5 Gy and sham irradiated mice, and this also manifests as a statistical trend in a 1-way ANOVA within this M Tg group ( Figure 4 C,D).