We found that females showed a trend toward higher acute glucose-stimulated insulin secretion response in C57BL/6J mice ( Figure 4 G), and significantly higher glucose-stimulated insulin secretion in 10- and 22-week-old Ins r f/f : Ins1 Cre −/− :nTnG +/− mice ( Figs.
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Sex differences in islet stress responses support female β cell resilience.
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