HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein.

7C ) that had been corrected for variations in corresponding Gag levels from three independent experiments, and we found that, whereas the change in cell-associated Env did not reach statistical significance, the GSN-induced change in virus-associated Env levels was indeed statistically significant ( Fig. 7C ).

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