Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature.

There was a trend of down-regulation of Mki67 , the gene coding for Ki-67 protein, that did not reach statistical significance (not shown), even though the percentage of Ki-67 + cells within spleen gag-specific CD8 T cells significantly dropped from 31.50 ± 9.16 at d30 to 5.36 ± 2.56 at d100 (averages ± Standard Deviation, Mann-Whitney test, P ≤ 0.05).

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