Tacrolimus induces a pro-fibrotic response in donor-derived human proximal tubule cells dependent on common variants of the CYP3A5 and ABCB1 genes.

Nephrol Dial Transplant · 2023 · PMC9976759 · PMID 35945682

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a significant trendno p-value reported

Interestingly, the M1/cleared tacrolimus shows a significant trend toward lower values at 300 vs. 50 ng/mL tacrolimus in both genetic variants.

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