Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration.

This finding is highly significant given that several independent studies have reported that plasma t-tau does not correlate with CSF t-tau 27–29 (as also demonstrated herein), which may be partly to blame for its poor diagnostic performance.

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While we observed differences between the Low Pathology versus each of the High ADNC and the High ADNC + Other subgroups at the group-level ( Table 1 ), these did not reach statistical significance probably because of the reduced statistical power.

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