Role of the caspase-8/RIPK3 axis in Alzheimer's disease pathogenesis and Aβ-induced NLRP3 inflammasome activation.

In contrast, depletion of RIPK3 alone on the 5xFAD background only resulted in a slight trend toward decreased D54D2 staining in the RS; however, this did not reach statistical significance ( Figure 2, C and D ).

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