Effect of mechanical unloading on genome-wide DNA methylation profile of the failing human heart.

JCI Insight · 2023 · PMC9977498 · PMID 36656640

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borderline significanceno p-value reported

RNA-Seq analysis in hiPSC-CMs suggested borderline significance for differential regulation of SMARCA4 by LINC00881 overexpression and knockdown , but not the other putative targets.

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did not reach statistical significanceno p-value reported

Using independent cardiac tissue samples obtained from patients with end-stage ICM and NICM, we validated upregulation of AKAP13 (fold change [FC] = 2.98) , HTRA1 (FC = 1.52) , EFCAB13 (FC = 2.86), and FBXO16 (FC = 1.92) as well as downregulation of TBX3 (FC = 0.39) in the failing human hearts by qPCR analysis, while changes in RPTOR and HDAC9 transcripts did not reach statistical significance ( Figure 4C ).

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