Noteworthily, the 15-month-old mice showed a trend toward decreased results in the Barnes maze and fear conditioning tests ( Figs. 2B–D ), although the decreases did not reach the level of statistical significance, indicating that 15 months might represent an age threshold for postoperative learning and memory impairment in mice.
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A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation.
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