Cluster analysis of plasma cytokines identifies two unique endotypes of children with asthma in the pediatric intensive care unit.

After adjusting for obesity, we found that Cluster 2 had an adjusted hazard ratio for a subsequent asthma exacerbation requiring systemic corticosteroids of 2.91 [95% CI 1.12–7.56, p = 0.028, n = 59] Although the proportion of children in Cluster 1 compared to Cluster 2 who had any medical visit for an asthma exacerbation in the year following discharge was higher for Cluster 2, this result did not reach statistical significance (24% vs. 70%, p = 0.063).

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However, we postulate that there may be significant variability within this population that has not been fully explored.

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