Spatial multi-omics revealed the impact of tumor ecosystem heterogeneity on immunotherapy efficacy in patients with advanced non-small cell lung cancer treated with bispecific antibody.

Furthermore, patients with high stromal signature scores had longer median OS (p=0.039) than those with low scores, but mPFS did not reach statistical significance (p=0.078) ( figure 5D, E ). 10.1136/jitc-2022-006234.supp19 Supplementary data 10.1136/jitc-2022-006234.supp20 Supplementary data 10.1136/jitc-2022-006234.supp21 Supplementary data To determine whether the signature of stromal regions remained effective in predicting the efficacy of general immunotherapy, we validated the spatially resolved signature constructed with relevant genes identified from the stromal area in an independent set of 65 patients with NSCLC treated with ICIs from public datasets ( online supplemental table S14 ).

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