Transcriptomic analysis of pathways associated with ITGAV/alpha(v) integrin-dependent autophagy in human B cells.

Although both the HDAC2 and OxPhos modules showed a trend toward upregulation upon stimulation in naïve B cells ( Figure 3J ), the autophagy-related genes themselves did not show upregulation upon stimulation in the naïve cells ( Figure 3K ), suggesting that the activation of autophagy does not simply reflect a response to increased metabolic activity after cell activation but instead reflect phenotypic changes acquired as B cells mature.

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