The lack of an immune response mediated by ILC1s also influenced the expression of two of the three tight junction protein genes analyzed ( Zo1 and Ocln ) in the ileum ( Figure 2h ), whereas, in the colon, only Ocln showed a trend to be increased in mice treated with the antibody AGM1 compared to untreated obese mice Supplemental Figure S2d).
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Intestinal group 1 innate lymphoid cells drive macrophage-induced inflammation and endocrine defects in obesity and promote insulinemia.
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