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The Macklin effect closely correlates with pneumomediastinum in acutely ill intubated patients with COVID-19 infection.

Clin Imaging · 2023 · PMC9984303 · PMID 36889115

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It may also be associated with development of pneumothorax, although the association did not reach statistical significance in the present study.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.