Mice deficient in synaptic protease neurotrypsin show impaired spaced long-term potentiation and blunted learning-induced modulation of dendritic spines.

Due to the large variance, the difference in the discrimination ratio did not reach statistical significance ( P = 0.184, 12.6% ± 5.0% vs. -4.5% ± 10.9%; Fig. 4 G right).

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Combined results indicate that there may be significant redundancy in the neuroanatomical regions and compensatory mechanisms mediating fear conditioning [ 32 ].

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Due to a slight trend for NT −/− mice to spend less time in the central area, the elevated plus maze was additionally used to verify whether these mice were more anxious.

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