Combining ASBT inhibitor and FGF15 treatments enhances therapeutic efficacy against cholangiopathy in female but not male Cyp2c70 KO mice.

The mRNA expression of liver fibrogenesis marker Collagen, type I, α1 (COL1A1) trended lower in the AAV-FGF15 treatment and the combined treatment groups, but not the GSK treatment group, although these changes did not reach statistical significance due to relatively large variations ( Fig. 3 E).

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