A modest reduction in OSMI-1–induced p38 phosphorylation was also observed with Tak1-targeting siRNA, whereas targeting Mlk3 did not reach statistical significance ( Fig. 6 , D and E ).
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Inhibiting O-GlcNAcylation impacts p38 and Erk1/2 signaling and perturbs cardiomyocyte hypertrophy.
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