Microglia specific deletion of miR-155 in Alzheimer's disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures.

Aβ 1–40 from insoluble protein fractions also trended downward in APP/PS1 mice after miR-155 knock-out microglia but did not reach statistical significance (Fig. 3 B; two-tailed unpaired t -test, p = 0.1607).

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