Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease.

Nat Neurosci · 2023 · PMC9991912 · PMID 36747024

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We further validated these results via smFISH-IHC; as suggested by NicheNet, Tgfbr1 and Itgb5 expression levels showed a trend towards dysregulation in microglia of App NL-F · Spp1 KO/KO versus App NL-F mice (Fig. 5e and Extended Data Fig. 6e,f ).

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