Epigenetic (re)programming of gene expression changes of CB1R and FAAH in the medial prefrontal cortex in response to early life and adolescence stress exposure.

Front Cell Neurosci · 2023 · PMC9992175 · PMID 36909279

Europe PMC DOI

hedged sentences

0.0002

closest p · 0.0× alpha

0.0835

boldest claim

The sentences

highly significantp = 0.0002actually significant

Relative gene expression Expression of cannabinoid receptor 1 (CB1R) is increased after ELS and FS Two-way ANOVA analysis revealed no significant main effects for ELS [ F (1,31) = 0.5555, p = 0.4617] or FS [ F (1,31) = 0.2117, p = 0.6487], but a highly significant interaction between these two stressors was found [ F (1,31) = 18.48, p = 0.0002].

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a strong trend toward significancep = 0.054so close (0.05 < p ≤ 0.1)

For the overall distance covered in the open field test, 2-way ANOVA analysis revealed a strong trend toward significance for ELS [ F (1,50) = 3.893, p = 0.054], but no effects for FS [ F (1,50) = 0.241, p = 0.6257] and interaction [ F (1,50) = 0.3193, p = 0.5745].

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a trend toward significancep = 0.0835so close (0.05 < p ≤ 0.1)

Results Behavioral tests Open field test (OF) and elevated plus maze (EPM) For the time spent in the center of the OF, 2-way ANOVA revealed a significant main effect for FS [ F (1,50) = 11.91, p = 0.0011], and a trend toward significance for ELS [ F (1,50) = 3.118, p = 0.0835] as well as for interaction [ F (1,50) = 3.322, p = 0.0743].

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