Interaction between maternal immune activation and peripubertal stress in rats: impact on cocaine addiction-like behaviour, morphofunctional brain parameters and striatal transcriptome.

Although there were no significant differences between groups in the overall analysis ( Χ 2 6 = 9.553; p = 0.1450), we observed that the group of LPS-exposed animals (without stress) had a strong trend ( Χ 2 2 = 5.887; p = 0.053) to have a higher proportion of rats displaying robust cocaine self-administration (greater “Normal acquisition” percentage).

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Fourth, we only found a trend towards significance in the PPI data, more specifically in the 12 dB 30 ms condition (Fig.

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