Inflammation and neuronal gene expression changes differ in early versus late chronic traumatic encephalopathy brain.

GO terms that trend toward significance (i.e. nominal p -value < 0.05) similarly showed substantial discordance in direction of effect for some GO terms (Figure 2 E), where processes related to immune response, inflammation, blood brain barrier, extracellular matrix/membrane, and metabolism were increased in high stage disease but decreased in low stage disease.

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4 A, Table 1 ), and unlike disease versus RHI DE genes, there is no apparent relationship between the direction of effect of these genes between CTE-L+RHI and CTE-H, and only 3 genes were nominally significant in both analyses (Figure 4 A).

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