Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis.

Whereas NT3 and NT4 were undetectable in all of the supernatants analyzed (data not shown), conditioned media from PAMP-activated cells showed increased levels of NGF and BDNF (although in the latter case, differences did not reach statistical significance at a α level of 0.05) (Fig. 3 a).

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