Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice.

The numerical reduction of REM sleep in the acute, 2 hr, time window following C21 injections did not reach statistical significance in this small sample of seven mice ( t (6) = 1.829, p=0.0585, Cohen’s d =–0.6972; Figure 4b ), but had an effect size comparable to that of the statistically significant REM sleep reduction in the same time window for the 5 mg/kg CNO condition (5 mg/kg CNO vs. saline: Cohen’s d =–0.5594).

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